J. Brad Shotwell

Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

Chan Chung, Stefan R. Sweha, Drew Pratt et al. · Cancer Cell · 2020 · 204 citations · Full text

Neuro-oncology, Somatic Variant, Tumor Heterogeneity +10

GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers

Peter Sabbatini, Susan Korenchuk, Jason L. Rowand et al. · Molecular Cancer Therapeutics · 2009 · 98 citations · Full text

Antitumor Activity, Immunology, Glucose Homeostasis +16

The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors

Edgar R. Wood, Randy K. Bledsoe, Jing Chai et al. · Journal of Biological Chemistry · 2015 · 79 citations · Full text

Negative Regulator, Autoimmune Disease, Allergy +10

Structure and Energetics of the Samarium Diiodide−HMPA Complex in Tetrahydrofuran

J. Brad Shotwell, Jennifer M. Sealy, Robert A. Flowers · The Journal of Organic Chemistry · 1999 · 71 citations

Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB

Michael F. Mesleh, Jason B. Cross, Jing Zhang et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 70 citations · Full text

Atpase Subunit, Aldo-keto Reductase, Biochemistry +11