Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome

Pooja Panwalkar, Jonathan R. Clark, Vijay Ramaswamy, +37

Acta Neuropathologica

Neuro-oncologyGlobal ReductionPowerful PredictorAutoimmune DiseaseHistopathology +4

Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

Chan Chung, Stefan R. Sweha, Drew Pratt, +21

Cancer Cell

Neuro-oncologySomatic VariantTumor HeterogeneityEpigenomic ReprogramingCancer Genomics +8

Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas

Jill Bayliss, Piali Mukherjee, Chao Lü, +22

Science Translational Medicine

Impaired proteolysis underlies autophagic dysfunction in Niemann–Pick type C disease

Matthew J. Elrick, Ting Yu, Chan Chung, +1

Human Molecular Genetics

Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

Sriram Venneti, Abed Rahman Kawakibi, Sunjong Ji, +81

Cancer Discovery

A Murine Niemann-Pick C1 I1061T Knock-In Model Recapitulates the Pathological Features of the Most Prevalent Human Disease Allele

Maria Praggastis, Brett A. Tortelli, Jessie Zhang, +13

Journal of Neuroscience

A synergistic small-molecule combination directly eradicates diverse prion strain structures

Blake E Roberts, Martin L. Duennwald, Huan Wang, +5

Nature Chemical Biology

BiochemistryBiomolecular Structure PredictionNatural SciencesStructural BioinformaticsMolecular Biology +7

Up-regulation of Cyclin D1 by HBx Is Mediated by NF-κB2/BCL3 Complex through κB Site of Cyclin D1 Promoter

Sung‐Gyoo Park, Chan Chung, Hang Won Kang, +2

Journal of Biological Chemistry

Transcriptional RegulationSignal TransductionSignaling PathwayCell RegulationMolecular Regulation +12

Odorant receptors in cancer

Chan Chung, Hee Jin Cho, ChaeEun Lee, +1

BMB Reports

Temporal and cell-specific deletion establishes that neuronal Npc1 deficiency is sufficient to mediate neurodegeneration

Ting Yu, Vikram G. Shakkottai, Chan Chung, +1

Human Molecular Genetics

Cell DeathNpc1 DeficiencyCellular NeurobiologySocial SciencesNeuroregeneration +19