EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

Michael T. McCabe, Heidi M. Ott, Gopinath Ganji, +19

Nature

Ezh2 InhibitionLymphoid NeoplasiaHematological MalignancyMedicinePathology +8

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss

Andrew Fedoriw, Satyajit Rajapurkar, Shane W. O’Brien, +43

Cancer Cell

Cancer ResearchMtap LossMedicinePharmacologyCell Death +8

VCaP, a cell-based model system of human prostate cancer.

Susan Korenchuk, J E Lehr, Lisa L. McLean, +5

PubMed

Rapid ("warm") autopsy study for procurement of metastatic prostate cancer.

Mark A. Rubin, MATTHEW J. PUTZI, Neil R. Mucci, +4

PubMed

Tumor BiologyUrologySurgical OncologyDirected AutopsiesTeam Members +13

BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models

Anastasia Wyce, Gopinath Ganji, Kimberly N. Smitheman, +16

PLoS ONE

Mycn Copy NumberBet Family ProteinsCell RegulationOncogenic AgentMedicine +12

Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer

Anastasia Wyce, Yan Degenhardt, Yuchen Bai, +8

Oncotarget

Over-express MycBet Bromodomain ProteinsUrologyOncogenic AgentMedicine +12

MIM, a Potential Metastasis Suppressor Gene in Bladder Cancer

Young-Goo Lee, Jill A. Macoska, Susan Korenchuk, +1

Neoplasia

Constitutive Activation of Signal Transducers and Activators of Transcription Predicts Vorinostat Resistance in Cutaneous T-Cell Lymphoma

Valeria R. Fantin, Andrey Loboda, Cloud P. Paweletz, +14

Cancer Research

Mechanism and Management of AKT Inhibitor-Induced Hyperglycemia

Ming‐Chih Crouthamel, Jason A. Kahana, Susan Korenchuk, +5

Clinical Cancer Research

GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers

Peter Sabbatini, Susan Korenchuk, Jason L. Rowand, +17

Molecular Cancer Therapeutics

Antitumor ActivityImmunologyGlucose HomeostasisExperimental ModelsInsulin Receptor +14