John M. Hatcher

Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development

Katherine A. Donovan, Fleur M. Ferguson, Jonathan W. Bushman et al. · Cell · 2020 · 346 citations · Full text

Geometric Modeling, Robotics, Engineering +11

Brain Penetrant LRRK2 Inhibitor

Hwan Geun Choi, Jinwei Zhang, Xianming Deng et al. · ACS Medicinal Chemistry Letters · 2012 · 130 citations · Full text

Wild-type Lrrk2, Pharmacotherapy, Synaptic Signaling +18

SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform

John M. Hatcher, Guowei Wu, Chuyue Zeng et al. · Cell chemical biology · 2018 · 126 citations · Full text

Anti-angiogenic Isoform, Angiogenesis, Covalent Srpk1/2 Inhibitor +10

Crystal structure of human IRAK1

Li Wang, Qi Qiao, Ryan Ferrao et al. · Proceedings of the National Academy of Sciences · 2017 · 84 citations · Full text

Copper(I)-Catalyzed Addition of Grignard Reagents to in Situ-Derived <i>N</i>-Sulfonyl Azoalkenes: An Umpolung Alkylation Procedure Applicable to the Formation of Up to Three Contiguous Quaternary Centers

John M. Hatcher, Don M. Coltart · Journal of the American Chemical Society · 2010 · 82 citations