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Cancer Discovery

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Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML

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Cell chemical biology

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CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

Hua Zhang, Camilla L. Christensen, Ruben Dries, +45

Cancer Cell

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Bruton tyrosine kinase degradation as a therapeutic strategy for cancer

Dennis Dobrovolsky, Eric S. Wang, Sara Morrow, +10

Blood

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer

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Nature Cancer

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Acute pharmacological degradation of Helios destabilizes regulatory T cells

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Nature Chemical Biology

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Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8

John M. Hatcher, Eric S. Wang, Liv Johannessen, +3

ACS Medicinal Chemistry Letters

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ACS Chemical Biology

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