Dietary eicosapentaenoic acid normalizes hippocampal omega-3 and 6 polyunsaturated fatty acid profile, attenuates glial activation and regulates BDNF function in a rodent model of neuroinflammation induced by central interleukin-1β administration

Yilong Dong, Min Xu, Allan V. Kalueff, +1

European Journal of Nutrition

InflammationDietary Eicosapentaenoic AcidOmega-3 Fatty AcidMedicinePharmacology +9

Efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn's disease: a phase 3, multicentre, randomised, double-blind, placebo-controlled and active-controlled, treat-through study

Marc Ferrante, Geert D’Haens, Vipul Jairath, +315

The Lancet

Moderately-to-severely Active CrohnImmunologyGastroenterologyClinical GastroenterologyUlcerative Colitis +3

Design, Synthesis, and Biological Evaluation of Deuterated <i>C</i>-Aryl Glycoside as a Potent and Long-Acting Renal Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes

Ge Xu, Binhua Lv, Jacques Y. Roberge, +16

Journal of Medicinal Chemistry

Urinary Glucose ExcretionOxidative StressMolecular PharmacologyBiological EvaluationRenal Pharmacology +14

Effects of curcumin in treatment of experimental pulmonary fibrosis: A comparison with hydrocortisone

Min Xu, Bin Deng, Yeuk-lung Chow, +2

Journal of Ethnopharmacology

InflammationFibrosisAntifibrotic TherapyInflammatory Lung DiseaseMedicine +5

Sodium-glucose cotransporters display sodium- and phlorizin-dependent water permeability

John D. Loike, SE Hickman, Kunyan Kuang, +5

American Journal of Physiology-Cell Physiology

Sglt-1 TypeCellular PhysiologyPf IncreaseSodium-glucose CotransportersMembrane Transport +17

The Melanogenesis-Inhibitory Effect and the Percutaneous Formulation of Ginsenoside Rb1

Lin Wang, Aiping Lü, Zhi‐Ling Yu, +8

AAPS PharmSciTech

MedicineMelanomaWound HealingPharmacologyCell Biology +1

C-Aryl glucosides substituted at the 4′-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

Baihua Xu, Feng Yan, Huawei Cheng, +18

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyDiabetes ManagementBiochemistryMedicineDiabetes +7

ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors

Baihua Xu, Feng Yan, Binhua Lv, +7

Bioorganic & Medicinal Chemistry

Molecular PharmacologyOrtho-substituted C-aryl GlucosidesRenal FunctionBiochemistryMedicine +5

Conformationally Constrained Spiro <i>C</i>‐Arylglucosides as Potent and Selective Renal Sodium‐Dependent Glucose Co‐transporter 2 (SGLT2) Inhibitors

Binhua Lv, Feng Yan, Jiajia Dong, +7

ChemMedChem

Leptin Attenuates Lipopolysaccharide or Oleic Acid-Induced Acute Lung Injury in Mice

Haiying Dong, Min Xu, Zhenyu Ji, +11

American Journal of Respiratory Cell and Molecular Biology

Acute Lung InjuryInflammatory Lung DiseaseLung InflammationImmunologyImmune System +16