Concepedia
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Theracos (United States)
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EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA1c levels in db/db mice and prolongs the survival of stroke-prone rats
Wenbin Zhang, Ajith Welihinda, Jordan Mechanic, +10
Pharmacological Research
Selective Sglt2 InhibitorMedicineDiabetesPharmacologyCell Death +11
2011
76
Design, Synthesis, and Biological Evaluation of Deuterated <i>C</i>-Aryl Glycoside as a Potent and Long-Acting Renal Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes
Ge Xu, Binhua Lv, Jacques Y. Roberge, +16
Journal of Medicinal Chemistry
Urinary Glucose ExcretionOxidative StressMolecular PharmacologyBiological EvaluationRenal Pharmacology +14
2014
63
A 96‐week, multinational, randomized, double‐blind, parallel‐group, clinical trial evaluating the safety and effectiveness of bexagliflozin as a monotherapy for adults with type 2 diabetes
Yuan‐Di C. Halvorsen, Geoffrey Walford, Joseph M. Massaro, +2
Diabetes Obesity and Metabolism
2019
39
Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors
Binhua Lv, Baihua Xu, Feng Yan, +12
Bioorganic & Medicinal Chemistry Letters
Medicinal ChemistryBiochemistryMedicineNatural SciencesDiabetes +7
2009
37
C-Aryl glucosides substituted at the 4′-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes
Baihua Xu, Feng Yan, Huawei Cheng, +18
Molecular PharmacologyDiabetes ManagementBiochemistryMedicineDiabetes +7
33
O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors
Baihua Xu, Binhua Lv, Feng Yan, +6
Molecular PharmacologyMedicinal ChemistryGlycosylationBiochemistryG Protein-coupled Receptor +8
26
A 96‐week, double‐blind, randomized controlled trial comparing bexagliflozin to glimepiride as an adjunct to metformin for the treatment of type 2 diabetes in adults
Yuan‐Di C. Halvorsen, John Paul Lock, Juan P. Frías, +4
2022
25
ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors
Baihua Xu, Feng Yan, Binhua Lv, +7
Bioorganic & Medicinal Chemistry
Molecular PharmacologyOrtho-substituted C-aryl GlucosidesRenal FunctionBiochemistryMedicine +5
2010
22
Conformationally Constrained Spiro <i>C</i>‐Arylglucosides as Potent and Selective Renal Sodium‐Dependent Glucose Co‐transporter 2 (SGLT2) Inhibitors
Binhua Lv, Feng Yan, Jiajia Dong, +7
ChemMedChem
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