Elizabeth Frias

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

Robert J. Ihry, Kathleen A. Worringer, Max R. Salick et al. · Nature Medicine · 2018 · 1K citations

Life Sciences, Genetics, Molecular Genetics +12

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

E. Robert McDonald, Antoine de Weck, Michael R. Schlabach et al. · Cell · 2017 · 701 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +17

DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks

Megan van Overbeek, Daniel Capurso, Matthew M. Carter et al. · Molecular Cell · 2016 · 503 citations · Full text

Life Sciences, Genetics, Molecular Biology +12

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

Gregory R. Hoffman, Rami Rahal, Frank P. Buxton et al. · Proceedings of the National Academy of Sciences · 2014 · 416 citations · Full text

Life Sciences, Genetics, Oncology +17

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

Christina H. Eng, Zuncai Wang, Diane Tkach et al. · Proceedings of the National Academy of Sciences · 2015 · 224 citations · Full text

Medicine, Oncology, Pharmacology +16