M. Ghate

The Structure of the Extracellular Region of Human Hepsin Reveals a Serine Protease Domain and a Novel Scavenger Receptor Cysteine-Rich (SRCR) Domain

John R. Somoza, Joseph D. Ho, Christine Luong et al. · Structure · 2003 · 85 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Discovery of 6-(2,4-Difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8<i>H</i>-pyrido[2,3-<i>d</i>]pyrimidin-7-one (Pamapimod) and 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2<i>H</i>-pyran-4-ylamino)pyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-one (R1487) as Orally Bioavailable and Highly Selective Inhibitors of p38α Mitogen-Activated Protein Kinase

David Goldstein, Michael Soth, Tobias Gabriel et al. · Journal of Medicinal Chemistry · 2011 · 74 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

X-ray crystal structure of JNK2 complexed with the p38α inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors

A. Kuglstatter, M. Ghate, Stan Tsing et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 41 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17

Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure–activity relationships of benzothiazine-substituted quinolinediones

Javier de Vicente, R. Hendricks, David B. Smith et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 35 citations

Life Sciences, Chemistry, Medicinal Chemistry +17

De Novo Fragment Design: A Medicinal Chemistry Approach to Fragment-Based Lead Generation

Francisco X. Talamás, Gloria Ao-Ieong, Ken A. Brameld et al. · Journal of Medicinal Chemistry · 2013 · 33 citations

Pharmacy, Chemistry, Medicinal Chemistry +17