Tadeusz K. Wyrzykiewicz

Statistics

Publications

Citations

840

H-Index

Active since

1989

Affiliations

Ionis Pharmaceuticals (United States)(Current)

Institute of Bioorganic Chemistry, Polish Academy of Sciences

Tadeusz K. Wyrzykiewicz is an author at Ionis Pharmaceuticals (United States) specializing in molecular biology, oligonucleotide chemistry, and oligonucleotide synthesis.

Publications per year

1989–2010

Publications

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

Eric E. Swayze, Andrew Siwkowski, Edward V. Wancewicz et al. · Nucleic Acids Research · 2006 · 461 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Human RNase H1 Discriminates between Subtle Variations in the Structure of the Heteroduplex Substrate

Walt F. Lima, J. Bart Rose, Josh G. Nichols et al. · Molecular Pharmacology · 2006 · 89 citations

Life Sciences, Biochemistry, Molecular Biology +17

Solid-Phase Oligodeoxynucleotide Synthesis: A Two-Step Cycle Using Peroxy Anion Deprotection

Agnieszka Sierzchała, Douglas J. Dellinger, Jason Betley et al. · Journal of the American Chemical Society · 2003 · 52 citations

Pharmacy, Biochemistry, Molecular Biology +13

Detecting low-level synthesis impurities in modified phosphorothioate oligonucleotides using liquid chromatography–high resolution mass spectrometry

Irena Nikčević, Tadeusz K. Wyrzykiewicz, Patrick A. Limbach · International Journal of Mass Spectrometry · 2010 · 50 citations · Full text

Pharmacy, Chemistry, Molecular Biology +14

The Positional Influence of the Helical Geometry of the Heteroduplex Substrate on Human RNase H1 Catalysis

Walt F. Lima, J. Bart Rose, Josh G. Nichols et al. · Molecular Pharmacology · 2006 · 38 citations

Life Sciences, Biochemistry, Molecular Biology +15

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