Douglas J. Dellinger

Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

Ayal Hendel, Rasmus O. Bak, Joseph T. Clark et al. · Nature Biotechnology · 2015 · 1.1K citations · Full text

Natural Sciences, Genetic Engineering, Molecular Biology +9

Improving CRISPR–Cas specificity with chemical modifications in single-guide RNAs

Daniel E. Ryan, David Taussig, Israel Steinfeld et al. · Nucleic Acids Research · 2017 · 268 citations · Full text

Systems Biology, Engineering, Off-target Effect +14

Streamlined Process for the Chemical Synthesis of RNA Using 2′-<i>O</i>-Thionocarbamate-Protected Nucleoside Phosphoramidites in the Solid Phase

Douglas J. Dellinger, Zoltán Tímár, Joel Myerson et al. · Journal of the American Chemical Society · 2011 · 72 citations

Solid Phase, Bioorganic Chemistry, Improved Method +18

Solid-Phase Chemical Synthesis of Phosphonoacetate and Thiophosphonoacetate Oligodeoxynucleotides

Douglas J. Dellinger, David M. Sheehan, Nanna K. Christensen et al. · Journal of the American Chemical Society · 2003 · 70 citations

Solid-Phase Oligodeoxynucleotide Synthesis:  A Two-Step Cycle Using Peroxy Anion Deprotection

Agnieszka Sierzchała, Douglas J. Dellinger, Jason Betley et al. · Journal of the American Chemical Society · 2003 · 52 citations

Bioorganic Chemistry, Engineering, Authentic Samples +17