Annie M. Hassell

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1<i>H</i>-indol-5-yl)-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

Jeffrey M. Axten, Jesús R. Medina, Yanhong Feng et al. · Journal of Medicinal Chemistry · 2012 · 619 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

The Drosophila Orphan Nuclear Receptor DHR38 Mediates an Atypical Ecdysteroid Signaling Pathway

K.D. Baker, Lisa M. Shewchuk, Tatiana Kozlova et al. · Cell · 2003 · 238 citations · Full text

Life Sciences, Entomology, Molecular Biology +8

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development

Jeffrey M. Axten, Stuart P. Romeril, Arthur Y. L. Shu et al. · ACS Medicinal Chemistry Letters · 2013 · 230 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP)

Curt D. Haffner, Caroline J. Diaz, Aaron B. Miller et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 62 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +7

Exploration of the P1 SAR of aldehyde cathepsin K inhibitors

John G. Catalano, David N. Deaton, Eric S. Furfine et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 36 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14