Imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1

Kristjan S. Gudmundsson, Sharon Boggs, John G. Catalano, +5

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineImidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine DerivativesAntiviral Drug DevelopmentAntiviral Drug +4

Amine substituted N-(1H-benzimidazol-2ylmethyl)-5,6,7,8-tetrahydro-8-quinolinamines as CXCR4 antagonists with potent activity against HIV-1

Kristjan S. Gudmundsson, Paul R. Sebahar, Leah D’Aurora Richardson, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineImmunologyAntiviral Drug DevelopmentAntiviral Therapy +8

Hepatitis C Replication Inhibitors That Target the Viral NS4B Protein

John F. Miller, Pek Y. Chong, J. Brad Shotwell, +21

Journal of Medicinal Chemistry

Viral ReplicationImmunologyMolecular BiologyAntiviral DrugSmall Molecules +17

Substituted tetrahydrocarbazoles with potent activity against human papillomaviruses

Kristjan S. Gudmundsson, Paul R. Sebahar, Leah D’Aurora Richardson, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePotent ActivityPharmacologyPharmaceutical Chemistry +2

Synthesis of a novel tricyclic 1,2,3,4,4a,5,6,10b-octahydro-1,10-phenanthroline ring system and CXCR4 antagonists with potent activity against HIV-1

John G. Catalano, Kristjan S. Gudmundsson, Angilique Svolto, +8

Bioorganic & Medicinal Chemistry Letters

Cxcr4 AntagonistsMedicinal ChemistryHeterocyclicMedicineNatural Sciences +8

Exploration of the P1 SAR of aldehyde cathepsin K inhibitors

John G. Catalano, David N. Deaton, Eric S. Furfine, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBiochemistryNatural SciencesMedicine +7

P2–P3 conformationally constrained ketoamide-based inhibitors of cathepsin K

David G. Barrett, Virginia M. Boncek, John G. Catalano, +16

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicineRational Drug DesignConformational Study +3

Structure/Activity Relationships in Lysophosphatidic Acid: The 2-Hydroxyl Moiety

Kevin R. Lynch, Darrin W. Hopper, Steven J. Carlisle, +3

Molecular Pharmacology

Potent and selective P2–P3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P1′, P1, and/or P3 substitutions

David G. Barrett, John G. Catalano, David N. Deaton, +8

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyPharmaceutical ChemistryGood Pharmacokinetic PropertiesBiochemistryMedicine +5

Design of small molecule ketoamide-based inhibitors of cathepsin K

John G. Catalano, David N. Deaton, Stacey T. Long, +5

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ChemistryNatural SciencesMedicineRational Drug Design +6