Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064

Adwoa Akwabi-Ameyaw, Jonathan Y. Bass, Richard D. Caldwell, +17

Bioorganic & Medicinal Chemistry Letters

Naphthoic Acid-based AnalogsBiochemistryG Protein-coupled ReceptorMedicineNatural Sciences +10

Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors

Curt D. Haffner, J. David Becherer, Eric E. Boros, +19

Journal of Medicinal Chemistry

Antiparasitic AgentNad LevelsPharmacotherapyMedicinal ChemistryNad Elevation +14

Glutamine Enhancement of Structure and Function in Transplanted Small Intestine in the Rat

Wendy L. Frankel, Wei Zhang, Juan L. Afonso, +8

Journal of Parenteral and Enteral Nutrition

Synthesis and Evaluation of Potent and Selective β₃ Adrenergic Receptor Agonists Containing Acylsulfonamide, Sulfonylsulfonamide, and Sulfonylurea Carboxylic Acid Isosteres

David Uehling, Kelly H. Donaldson, David N. Deaton, +13

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistrySelective BetaFunctional SelectivityMedicine +10

FXR agonist activity of conformationally constrained analogs of GW 4064

Adwoa Akwabi-Ameyaw, Jonathan Y. Bass, Richard D. Caldwell, +14

Bioorganic & Medicinal Chemistry Letters

G Protein-coupled ReceptorFunctional SelectivityMolecular BiologyConformational StudyFxr Agonist Activity +2

Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene

Jonathan Y. Bass, Justin A. Caravella, Lihong Chen, +14

Bioorganic & Medicinal Chemistry Letters

Drug TargetFunctional SelectivityMedicineHeteroaryl ReplacementsFarnesoid X Receptor +6

Variable sac behavior after endovascular repair of abdominal aortic aneurysm: analysis of core laboratory data

Roy K. Greenberg, David N. Deaton, Timothy M. Sullivan, +7

Journal of Vascular Surgery

Core Laboratory DataEndovascular TechniqueAbdominal Aortic AneurysmVascular SurgerySurgery +5

Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064

Jonathan Y. Bass, Richard D. Caldwell, Justin A. Caravella, +11

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryFunctional SelectivityMedicineReceptor (Biochemistry) +7

Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38

J. David Becherer, Eric E. Boros, Tiffany Carpenter, +16

Journal of Medicinal Chemistry

PharmacotherapyChemical BiologyExperimental PharmacologyPharmaceutical ChemistryTranslational Pharmacology +15

Matrix Metalloproteinase Inhibitors Containing a [(Carboxyalkyl)amino]zinc Ligand: Modification of the P1 and P2' Residues

Frank K. Brown, Peter J. Brown, D. Mark Bickett, +6

Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryImide GroupNatural SciencesEnzymes Collagenase +13