David Uehling

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

Matthew W. Harding, David Uehling, Stuart L. Schreiber · Nature · 1989 · 1.4K citations

Molecular Immunology, Signal Transduction, Protein Expression +7

Total synthesis of FK506 and an FKBP probe reagent, [C(8),C(9)-13C2]-FK506

Masashi Nakatsuka, John A. Ragan, Tarek Sammakia et al. · Journal of the American Chemical Society · 1990 · 258 citations

Molecular Sciences, Chemical Measurement, Chemical Analysis +13

Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors

Tara Rheault, John Stellwagen, George M. Adjabeng et al. · ACS Medicinal Chemistry Letters · 2013 · 253 citations · Full text

B-raf-driven Tumors, Antitumor Activity, Hyperactive Signaling +16

Dabrafenib; Preclinical Characterization, Increased Efficacy when Combined with Trametinib, while BRAF/MEK Tool Combination Reduced Skin Lesions

Alastair J. King, Marc R. Arnone, Maureen R. Bleam et al. · PLoS ONE · 2013 · 212 citations · Full text

Dermatology, Tumor Biology, Signaling Pathway +17

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma

Xueqing Lun, J. Connor Wells, Natalie Grinshtein et al. · Clinical Cancer Research · 2016 · 196 citations