Alastair J. King

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

Alastair J. King, Huaiyu Sun, Bruce Diaz et al. · Nature · 1998 · 430 citations

Signal Transduction, Signaling Pathway, Cell Regulation +8

Increased cyclin D1 expression can mediate BRAF inhibitor resistance in <i>BRAF</i> V600E–mutated melanomas

Keiran S.M. Smalley, Mercedes Lioni, Maurizia Dalla Palma et al. · Molecular Cancer Therapeutics · 2008 · 293 citations · Full text

Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic <i>BRAF</i> by the Kinase Inhibitor SB-590885

Alastair J. King, Denis R. Patrick, Roberta S. Batorsky et al. · Cancer Research · 2006 · 262 citations · Full text

Pathology, Oncogenic Braf Alleles, Tumor Biology +17

Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors

Tara Rheault, John Stellwagen, George M. Adjabeng et al. · ACS Medicinal Chemistry Letters · 2013 · 253 citations · Full text

B-raf-driven Tumors, Antitumor Activity, Hyperactive Signaling +16

Dabrafenib; Preclinical Characterization, Increased Efficacy when Combined with Trametinib, while BRAF/MEK Tool Combination Reduced Skin Lesions

Alastair J. King, Marc R. Arnone, Maureen R. Bleam et al. · PLoS ONE · 2013 · 212 citations · Full text

Dermatology, Tumor Biology, Signaling Pathway +17