Pawan Bir Kohli

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

Ingrid E. Wertz, Saritha Kusam, Cynthia Lam et al. · Nature · 2011 · 810 citations

Medicine, Molecular Biology, Oncology +7

Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton’s Tyrosine Kinase Inhibitor in Early Clinical Development

James J. Crawford, Adam R. Johnson, Dinah Misner et al. · Journal of Medicinal Chemistry · 2018 · 247 citations · Full text

Medicine, Immunology, Pharmacology +17

Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

Patrick J. Lupardus, Mark Ultsch, Heidi J.A. Wallweber et al. · Proceedings of the National Academy of Sciences · 2014 · 220 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

Snahel Patel, Joshua D. Webster, Eugene Varfolomeev et al. · Cell Death and Differentiation · 2019 · 146 citations · Full text

Medicine, Cancer Biology, Oncology +9

Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations

Adam R. Johnson, Pawan Bir Kohli, Arna Katewa et al. · ACS Chemical Biology · 2016 · 134 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17