Heidi J.A. Wallweber

Author

Also Known As

H.J. Wallweber, H.J.A. Wallweber, Heidi J A Wallweber, Heidi J. A. Wallweber, Heidi J. Wallweber, Heidi J.A Wallweber, Heidi J.A. Wallweber, Heidi JA Wallweber, Heidi Wallweber, Heidi J.A. Wallweber

Publications

4.4K

Citations

H-Index

Concepts

All Affiliations

Molecular Oncology (United States)Gene Therapy Laboratory Genentech Charles River Laboratories (United Kingdom)PDL BioPharma (United States)

About

Heidi J.A. Wallweber is an author at Molecular Oncology (United States) specializing in medicine, pharmacology, and natural sciences.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	15	15	3.3K
2	Natural Sciences	8	8	962
3	Biochemistry	7	7	746
4	Engineering	1	1	94
5	Social Sciences	1	1	102

Heidi J.A. Wallweber

Publications

4.4K

Citations

H-Index

Page 1

	Year	Citations
IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis Eugene Varfolomeev, John W. Blankenship, Sarah M. Wayson, Cell InflammationCytokineInduce AutoubiquitinationSignal TransductionMedicine	2007	1.2K
The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer Adrian Folkes, Khatereh Ahmadi, W. Alderton, Journal of Medicinal Chemistry Pi3 KinaseChemoprevention StrategyPharmacotherapyPharmaceutical ChemistryTumor Biology	2008	739
Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152) John A. Flygare, Maureen H. Beresini, Nageshwar Budha, Journal of Medicinal Chemistry ApoptosisCell DeathClinical CandidatePharmacotherapyImmunotherapeutics	2012	247
Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination Erin C. Dueber, Allyn J. Schoeffler, Andreas Lingel, Science Protein FunctionMolecular PhysiologySignal TransductionRing DimerizationG Protein-coupled Receptor	2011	225
Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition Patrick J. Lupardus, Mark Ultsch, Heidi J.A. Wallweber, Proceedings of the National Academy of Sciences	2014	211
Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs Kerry Zobel, Lan Wang, Eugene Varfolomeev, ACS Chemical Biology C-iaps 1Protein AssemblySmac InteractionsApoptosisCell Death	2006	174
Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function David H. Hackos, Patrick J. Lupardus, Teddy Grand, Neuron Glun2a-containing NmdarsBiochemistryNatural SciencesPositive Allosteric ModulatorsNeuropharmacology	2016	170
Structures of APRIL-Receptor Complexes S.G. Hymowitz, Darshana Patel, Heidi J.A. Wallweber, Journal of Biological Chemistry ImmunologyMolecular BiologyCancer BiologyTumor BiologySignaling Pathway	2004	164
Structural basis of recognition of interferon-α receptor by tyrosine kinase 2 Heidi J.A. Wallweber, Christine Tam, Yvonne Franke, Nature Structural & Molecular Biology Signal TransductionSignaling PathwayTyrosine Kinase 2Receptor Tyrosine KinaseImmunology	2014	143
Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP Domagoj Vucic, Matthew C. Franklin, Heidi J.A. Wallweber, Biochemical Journal	2004	133

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