Heidi J.A. Wallweber

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Eugene Varfolomeev, John W. Blankenship, Sarah M. Wayson et al. · Cell · 2007 · 1.2K citations · Full text

Inflammation, Cytokine, Induce Autoubiquitination +12

The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

Adrian Folkes, Khatereh Ahmadi, W. Alderton et al. · Journal of Medicinal Chemistry · 2008 · 739 citations · Full text

Pi3 Kinase, Chemoprevention Strategy, Pharmacotherapy +18

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

John A. Flygare, Maureen H. Beresini, Nageshwar Budha et al. · Journal of Medicinal Chemistry · 2012 · 247 citations · Full text

Apoptosis, Cell Death, Clinical Candidate +20

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

Erin C. Dueber, Allyn J. Schoeffler, Andreas Lingel et al. · Science · 2011 · 225 citations

Protein Function, Molecular Physiology, Signal Transduction +15

Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

Patrick J. Lupardus, Mark Ultsch, Heidi J.A. Wallweber et al. · Proceedings of the National Academy of Sciences · 2014 · 211 citations · Full text