Victor K. Johnston

Identification and Biological Characterization of Heterocyclic Inhibitors of the Hepatitis C Virus RNA-dependent RNA Polymerase

Dashyant Dhanak, Kevin J. Duffy, Victor K. Johnston et al. · Journal of Biological Chemistry · 2002 · 196 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

3-(1,1-Dioxo-2<i>H</i>-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1<i>H</i>)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

Rosanna Tedesco, Antony N. Shaw, Ramesh Bambal et al. · Journal of Medicinal Chemistry · 2006 · 160 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine:  Discovery of <i>N</i> -[(3 <i>R</i> ,6 <i>S</i> )-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1 <i>H</i> -imidazo[4,5- <i>b</i> ]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)

Daniel V. Paone, Anthony W. Shaw, Diem N. Nguyen et al. · Journal of Medicinal Chemistry · 2007 · 146 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Pharmacological Characterization of MK-0974 [N-[(3 R,6 S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1 H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine

Christopher Salvatore, James C. Hershey, Halea A. Corcoran et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 146 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor

Tammy Nguyen, Adam Gates, Lester L. Gutshall et al. · Antimicrobial Agents and Chemotherapy · 2003 · 89 citations · Full text

Life Sciences, Microbiology, Molecular Biology +17