Genome-Scale RNAi Screen for Host Factors Required for HIV Replication

Honglin Zhou, Min Xu, Qian Huang, +8

Cell Host & Microbe

Viral ReplicationHost FactorNatural SciencesHuman RetrovirusMolecular Biology +7

MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

Vincenzo Summa, Steven W. Ludmerer, John A. McCauley, +22

Antimicrobial Agents and Chemotherapy

Identification and Biological Characterization of Heterocyclic Inhibitors of the Hepatitis C Virus RNA-dependent RNA Polymerase

Dashyant Dhanak, Kevin J. Duffy, Victor K. Johnston, +23

Journal of Biological Chemistry

A Limited Group of Class I Histone Deacetylases Acts To Repress Human Immunodeficiency Virus Type 1 Expression

Kara S. Keedy, Nancie M. Archin, Adam Gates, +3

Journal of Virology

Hdac InhibitorsEpigenetic ChangeImmunologyMolecular BiologyImmunotherapy +18

3-(1,1-Dioxo-2<i>H</i>-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1<i>H</i>)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

Rosanna Tedesco, Antony N. Shaw, Ramesh Bambal, +19

Journal of Medicinal Chemistry

First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

Sethu Sankaranarayanan, Marie A. Holahan, Dennis Colussi, +35

Journal of Pharmacology and Experimental Therapeutics

Robust Statistical Methods for Hit Selection in RNA Interference High-Throughput Screening Experiments

Xiaohua Douglas Zhang, Xiting Cindy Yang, Namjin Chung, +6

Pharmacogenomics

<i>LRRTM3</i> promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease

John Majercak, William J. Ray, Amy S. Espeseth, +26

Proceedings of the National Academy of Sciences

Molecular BiologySynaptic SignalingLate-onset AlzheimerAlzheimer's DiseaseBace1 Cleavage +19

Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor

Tammy Nguyen, Adam Gates, Lester L. Gutshall, +4

Antimicrobial Agents and Chemotherapy

ROCK Controls Matrix Synthesis in Vascular Smooth Muscle Cells

René Chapados, Khotaro Abe, Kaori Ihida‐Stansbury, +8

Circulation Research

EngineeringA10 SmcsCytoskeletonCellular PhysiologySmc Spreading +15