Concepedia

Pharmacological Characterization of MK-0974 [N-[(3 R,6 S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1 H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine

Christopher Salvatore, James C. Hershey, Halea A. Corcoran, John F. Fay, Victor K. Johnston, Eric L. Moore, Scott D. Mosser, Christopher S. Burgey, Daniel V. Paone, Anthony W. Shaw,

Journal of Pharmacology and Experimental Therapeutics · 2007 · 146 citations · 22 references

DOI

Concepts

References

22

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

Linda M. McLatchie, Neil J. Fraser, Martin J. Main et al. · Nature · 1998 · 2.1K citations

, , +14

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

Susan Amara, Vivian Jonas, Michael G. Rosenfeld et al. · Nature · 1982 · 2.1K citations

, , +15

Vasoactive peptide release in the extracerebral circulation of humans during migraine headache

Peter J. Goadsby, Lars Edvinsson, Rolf Ekman · Annals of Neurology · 1990 · 1.6K citations

, , +14

Calcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine

Jes Olesen, Hans‐Christoph Diener, Ingo W. Husstedt et al. · New England Journal of Medicine · 2004 · 1.2K citations · Full text

, , +16

The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats

Peter J. Goadsby, Lars Edvinsson · Annals of Neurology · 1993 · 1.2K citations

, , +17