Diem N. Nguyen

Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine:  Discovery of <i>N</i> -[(3 <i>R</i> ,6 <i>S</i> )-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1 <i>H</i> -imidazo[4,5- <i>b</i> ]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)

Daniel V. Paone, Anthony W. Shaw, Diem N. Nguyen et al. · Journal of Medicinal Chemistry · 2007 · 146 citations · Full text

Increased Levels of Keratin 16 Alter Epithelialization Potential of Mouse Skin Keratinocytes In Vivo and Ex Vivo

Matthew Wawersik, Stacy Mazzalupo, Diem N. Nguyen et al. · Molecular Biology of the Cell · 2001 · 70 citations · Full text

Keratin 16, Adult Skin, Dermatology +16

Synthesis of the (3<i>R</i>,6<i>S</i>)-3-Amino-6-(2,3-difluorophenyl)azepan-2-one of Telcagepant (MK-0974), a Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine Headache

Christopher S. Burgey, Daniel V. Paone, Anthony W. Shaw et al. · Organic Letters · 2008 · 60 citations

Combinatorial Chemistry, Bioorganic Chemistry, Organic Chemistry +17

Non-peptide calcitonin gene-related peptide receptor antagonists from a benzodiazepinone lead

Theresa M. Williams, Craig A. Stump, Diem N. Nguyen et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 52 citations · Full text

Biochemistry, Medicine, Receptor (Biochemistry) +7

Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: Optimization of the 4-substituted piperidine

Christopher S. Burgey, Craig A. Stump, Diem N. Nguyen et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 51 citations · Full text

Biochemistry, Functional Selectivity, Medicine +8