Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine:  Discovery of <i>N</i> -[(3 <i>R</i> ,6 <i>S</i> )-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1 <i>H</i> -imidazo[4,5- <i>b</i> ]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)

Daniel V. Paone, Anthony W. Shaw, Diem N. Nguyen, +13

Journal of Medicinal Chemistry

Increased Levels of Keratin 16 Alter Epithelialization Potential of Mouse Skin Keratinocytes In Vivo and Ex Vivo

Matthew Wawersik, Stacy Mazzalupo, Diem N. Nguyen, +1

Molecular Biology of the Cell

Keratin 16Adult SkinDermatologySkin RegenerationInflammation +14

Synthesis of the (3<i>R</i>,6<i>S</i>)-3-Amino-6-(2,3-difluorophenyl)azepan-2-one of Telcagepant (MK-0974), a Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine Headache

Christopher S. Burgey, Daniel V. Paone, Anthony W. Shaw, +6

Organic Letters

Combinatorial ChemistryBioorganic ChemistryOrganic ChemistryPeptide SciencePharmacotherapy +15

Non-peptide calcitonin gene-related peptide receptor antagonists from a benzodiazepinone lead

Theresa M. Williams, Craig A. Stump, Diem N. Nguyen, +15

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineReceptor (Biochemistry)Neuropeptide ReceptorPharmacotherapy +5

Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: Optimization of the 4-substituted piperidine

Christopher S. Burgey, Craig A. Stump, Diem N. Nguyen, +12

Bioorganic & Medicinal Chemistry Letters

BiochemistryFunctional SelectivityMedicineReceptor AntagonistsNeuropeptide Receptor +6

Caprolactams as potent CGRP receptor antagonists for the treatment of migraine

Anthony W. Shaw, Daniel V. Paone, Diem N. Nguyen, +10

Bioorganic & Medicinal Chemistry Letters

MedicinePharmacological AgentNeuropharmacologyPharmacotherapyPharmacology +1

Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine

Brendan M. Crowley, Craig A. Stump, Diem N. Nguyen, +22

Bioorganic & Medicinal Chemistry Letters

Acute TreatmentGene-related PeptideMedicineReceptor AntagonistsNeuropeptide Receptor +5

Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I

Diem N. Nguyen, Craig A. Stump, Eileen S. Walsh, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePotent InhibitorsPharmacologyPharmaceutical Chemistry +2

Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: Discovery of MK-2918

Daniel V. Paone, Diem N. Nguyen, Anthony W. Shaw, +11

Bioorganic & Medicinal Chemistry Letters

Bioavailable ImidazoazepanesBiochemistryFunctional SelectivityMedicineReceptor Antagonists +8

Calcitonin gene-related peptide (CGRP) receptor antagonists: Investigations of a pyridinone template

Diem N. Nguyen, Daniel V. Paone, Anthony W. Shaw, +11

Bioorganic & Medicinal Chemistry Letters

Signal TransductionBiochemistryFunctional SelectivityMedicineReceptor Antagonists +9