Discovery, Synthesis, and <i>in Vivo</i> Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase

Andrew Mortlock, Kevin M. Foote, Nicola M. Heron, +28

Journal of Medicinal Chemistry

Pharmaceutical ScienceSelective InhibitorsPharmacotherapyAurora BChemical Biology +15

Synthesis and Biological Evaluation of Aryl-phospho-indole as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors

François-René Alexandre, Agnès Amador, Stéphanie Bot, +12

Journal of Medicinal Chemistry

Medicinal ChemistryWild-type Hiv-1BiochemistryMedicineNatural Sciences +11

Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors

Frédéric Jung, Georges Pasquet, Christine Lambert‐van der Brempt, +20

Journal of Medicinal Chemistry

Planar ConformationPharmacotherapySelective Aurora AHeterocycle ChemistryChemical Biology +17

Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor

Cyril B. Dousson, François-René Alexandre, Agnès Amador, +24

Journal of Medicinal Chemistry

Medicinal ChemistryDrug Resistant VirusMedicineNatural SciencesAntiviral Drug Development +11

The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2′-α-chloro-2′-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors

François-René Alexandre, Eric Badaroux, John P. Bilello, +30

Bioorganic & Medicinal Chemistry Letters

MedicineAntiviral Drug DevelopmentAntiviral TherapyMolecular BiologyHepatitis +7

Asymmetric hydrogenation reactions mediated by a new class of bicyclic bisphosphinites

Nadine Derrien, Cyril B. Dousson, Stanley M. Roberts, +3

Tetrahedron Asymmetry

Chemical EngineeringNovel OrganocatalystsEngineeringOrganic ChemistryNew Class +6

Synthesis and Antiviral Evaluation of Carbocyclic Nucleoside Analogs of Nucleoside Reverse Transcriptase Translocation Inhibitor MK-8591 (4′-Ethynyl-2-fluoro-2′-deoxyadenosine)

François-René Alexandre, Rachid Rahali, Houcine Rahali, +9

Journal of Medicinal Chemistry

Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase

Claire Pierra Rouvière, Agnès Amador, Eric Badaroux, +20

Bioorganic & Medicinal Chemistry Letters

Viral PolymeraseMedicineDrug DiscoveryAntiviral Drug DevelopmentAntiviral Therapy +6

Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor

Jean‐Laurent Paparin, Agnès Amador, Eric Badaroux, +23

Bioorganic & Medicinal Chemistry Letters

Development and Scale-Up of a Manufacturing Route for the Non-nucleoside Reverse Transcriptase Inhibitor GSK2248761A (IDX-899): Synthesis of an Advanced Key Chiral Intermediate

Richard K. Bellingham, Gary T. Borrett, Guillaume Bret, +21

Organic Process Research & Development

Manufacturing RouteEngineeringPhosphinate Ester Gsk2248761aBiochemistryEnantioselective Synthesis +13