Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy

Else Driehuis, Sigrid Kolders, Sacha Spelier, +25

Cancer Discovery

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Tanja Rothgangl, Melissa K. Dennis, Paulo J.C. Lin, +29

Nature Biotechnology

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

Camilla Calandrini, Frans Schutgens, Rurika Oka, +28

Nature Communications

Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis

Fernando G. Osorio, Axel Rosendahl Huber, Rurika Oka, +7

Cell Reports

Prime editing for functional repair in patient-derived disease models

Imre F. Schene, Indi P. Joore, Rurika Oka, +9

Nature Communications

CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

Maarten H. Geurts, Eyleen de Poel, Gimano D. Amatngalim, +20

Cell stem cell

EngineeringMedicineGeneticsSynthetic BiologyGenetic Engineering +8

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

Benedetta Artegiani, Lisa van Voorthuijsen, Rik G.H. Lindeboom, +15

Cell stem cell

Molecular BiologyGene EditingGenome EditingTumor Suppressor FunctionTumor Suppressor +4

Genome-wide mapping of transcriptional enhancer candidates using DNA and chromatin features in maize

Rurika Oka, Johan Zicola, Blaise Weber, +8

Genome biology

Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer

Kadi Lõhmussaar, Rurika Oka, Jose Espejo Valle-Inclán, +12

Cell stem cell

Viral OncogenesisCervical Cancer ManagementCervical CancerOncogenic AgentPathology +7

MutationalPatterns: the one stop shop for the analysis of mutational processes

Freek Manders, Arianne M. Brandsma, Jurrian K. de Kanter, +7

BMC Genomics