Claire McWhirter

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

Vanessa Rodrik-Outmezguine, Masanori Okaniwa, Zhan Yao et al. · Nature · 2016 · 469 citations

Medicine, Mtor Resistance Mutations, Molecular Biology +4

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

Diana Zatreanu, Helen M.R. Robinson, Omar Alkhatib et al. · Nature Communications · 2021 · 336 citations · Full text

Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site

Jack Exell, Mark J. Thompson, L. David Finger et al. · Nature Chemical Biology · 2016 · 75 citations · Full text

Molecular Pharmacology, Substrate Entry, Drug Target +10

Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88^L265P Diffuse Large B-Cell Lymphoma

James S. Scott, Sébastien L. Degorce, Rana Anjum et al. · Journal of Medicinal Chemistry · 2017 · 56 citations · Full text

Mechanistic Study of Protein Phosphatase-1 (PP1), A Catalytically Promiscuous Enzyme

Claire McWhirter, Elizabeth A. Lund, Eric A. Tanifum et al. · Journal of the American Chemical Society · 2008 · 46 citations · Full text