A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants

Katie J. Ryan, Charles C. White, K R Patel, +16

Science Translational Medicine

Neurodegenerative DiseasesGenetic VariantsAlzheimer's DiseaseMedicineDegenerative Pathology +9

Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons

Jason Schapansky, Saurabh Khasnavis, Mark P. DeAndrade, +7

Neurobiology of Disease

Neurodegenerative DiseasesMolecular NeuroscienceFamilial Knockin MutationSynaptic SignalingGenetic Disorder +10

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

Priya Srikanth, Karam Han, Dana G. Callahan, +7

Cell Reports

Intervertebral DiscGeneticsGenomic MechanismEpigeneticsSignaling Pathway +21

JUMP Cell Painting dataset: morphological impact of 136,000 chemical and genetic perturbations

Srinivas Niranj Chandrasekaran, Jeanelle Ackerman, Eric Alix, +95

EngineeringGeneticsDigital PathologyPathologyTumor Biology +22

A High Content Drug Screen Identifies Ursolic Acid as an Inhibitor of Amyloid β Protein Interactions with Its Receptor CD36

Kim Wilkinson, Justin D. Boyd, Marcie A. Glicksman, +2

Journal of Biological Chemistry

Drug TargetCellular PharmacologyNeurochemical BiomarkersPeptide SciencePharmaceutical Chemistry +16

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease

Ming Jin, Brian O’Nuallain, Wei Hong, +9

Nature Communications

GSTπ expression mediates dopaminergic neuron sensitivity in experimental parkinsonism

Michelle Smeyne, Justin D. Boyd, Kennie R. Shepherd, +6

Proceedings of the National Academy of Sciences

Neurodegenerative DiseasesMolecular NeuroscienceBiochemistryMedicineGstπ Expression +11

A High-Content Screen Identifies Novel Compounds That Inhibit Stress-Induced TDP-43 Cellular Aggregation and Associated Cytotoxicity

Justin D. Boyd, J. Peter Lee-Armandt, Marisa S. Feiler, +7

SLAS DISCOVERY

Isoflurane Decreases Self-renewal Capacity of Rat Cultured Neural Stem Cells

Deborah J. Culley, Justin D. Boyd, Arvind Palanisamy, +5

Anesthesiology

Angiogenic Factors Stimulate Growth of Adult Neural Stem Cells

Andreas Androutsellis‐Theotokis, Maria Adele Rueger, Deric M. Park, +9

PLoS ONE