Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy

Jason Schapansky, Jonathan Nardozzi, F. Felizia, +1

Human Molecular Genetics

MitophagyInnate Immune SystemImmunologyInnate ImmunityImmune System +22

Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

Subir Roy Chowdhury, Darrell R. Smith, Ali Saleh, +7

Brain

Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility

Evgeny Shlevkov, Tal Kramer, Jason Schapansky, +2

Proceedings of the National Academy of Sciences

Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons

Jason Schapansky, Saurabh Khasnavis, Mark P. DeAndrade, +7

Neurobiology of Disease

Neurodegenerative DiseasesMolecular NeuroscienceFamilial Knockin MutationSynaptic SignalingGenetic Disorder +10

Activation of Nuclear Factor-κB via Endogenous Tumor Necrosis Factor α Regulates Survival of Axotomized Adult Sensory Neurons

Paul Fernyhough, Darrell R. Smith, Jason Schapansky, +7

Journal of Neuroscience

Sensory Neurons Derived from Diabetic Rats Have Diminished Internal Ca ²⁺ Stores Linked to Impaired Re-uptake by the Endoplasmic Reticulum

Elena Zherebitskaya, Jason Schapansky, Eli Akude, +5

ASN NEURO

Sensory NeuronsSynaptic TransmissionImpaired Re-uptakeCa2+ UptakeNeurotransmission +20

NF-κB activated by ER calcium release inhibits Aβ-mediated expression of CHOP protein: Enhancement by AD-linked mutant presenilin 1

Jason Schapansky, Kelly L. Olson, Randy Van der Ploeg, +1

Experimental Neurology

InflammationNeuroinflammationSignal TransductionMolecular PhysiologyChop Protein +9

Evidence for the involvement of calbindin D28k in the presenilin 1 model of Alzheimer's disease

Gary Odero, Kensuke Oikawa, Kathryn A. C. Glazner, +8

Neuroscience

Alzheimer's DiseaseMolecular NeuroscienceDementiaNeurochemical BiomarkersSocial Sciences +8

Strain specific differences in memory and neuropathology in a mouse model of Alzheimer's disease

Kathryn A. C. Glazner, Gary Odero, Everet Anema, +6

Life Sciences

Alzheimer's DiseaseDementiaMemoryVascular DementiaNeurochemical Biomarkers +10

Early growth response 2 (Egr-2) expression is triggered by NF-κB activation

Solmaz Nafez, Kensuke Oikawa, Gary Odero, +14

Molecular and Cellular Neuroscience

InflammationTranscriptional RegulationSignal TransductionSignaling PathwayCell Regulation +9