Concepedia

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants

Katie J. Ryan, Charles C. White, K R Patel, Jishu Xu, Marta Olah, Joseph M. Replogle, Michael Frangieh, Maria Cimpean, Phoebe A. Winn, Allison McHenry,

Science Translational Medicine · 2017 · 167 citations · 64 references

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Abstract

A microglial-like cellular model can be used to identify functional consequences of genetic variants associated with neurodegenerative disease.

References

64

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

Bo Li, Colin N. Dewey · BMC Bioinformatics · 2011 · 22.5K citations · Full text

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Elisabetta Polazzi, Ilaria Mengoni, Marco Caprini et al. · Neurosignals · 2012 · 9K citations · Full text

De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis

Brian J. Haas, Alexie Papanicolaou, Moran Yassour et al. · Nature Protocols · 2013 · 8.7K citations

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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Florent Ginhoux, Melanie Greter, Marylène Leboeuf et al. · Science · 2010 · 4.9K citations · Full text

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Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

Alexander Zimprich, Saskia Biskup, Petra Leitner et al. · Neuron · 2004 · 3K citations · Full text

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