Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Nikolaos A. Patsopoulos, Sergio E. Baranzini, Adam Santaniello, +130

Science

ImmunologyExtended MhcInnate ImmunityImmune SystemImmune-related Gene Polymorphism +14

Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

Marta Olah, Vilas Menon, Naomi Habib, +24

Nature Communications

A transcriptomic atlas of aged human microglia

Marta Olah, Ellis Patrick, Alexandra–Chloé Villani, +17

Nature Communications

Transcriptomic AtlasNeurodegenerative DiseasesGlobal Human PopulationAlzheimer's DiseaseAging +13

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants

Katie J. Ryan, Charles C. White, K R Patel, +16

Science Translational Medicine

Neurodegenerative DiseasesGenetic VariantsAlzheimer's DiseaseMedicineDegenerative Pathology +9

CD33 modulates TREM2: convergence of Alzheimer loci

Gail Chan, Charles C. White, Phoebe A. Winn, +12

Nature Neuroscience

Alzheimer's DiseaseMedicineAlzheimer LociNeuroscienceMolecular Neurobiology +3

Deconvolving the contributions of cell-type heterogeneity on cortical gene expression

Ellis Patrick, Mariko Taga, Ayla Ergün, +10

PLoS Computational Biology

Cortical Gene ExpressionCellular NeurobiologySocial SciencesBiostatisticsNeurology +20

The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility

NA Patsopoulos, Sergio E. Baranzini, Adam Santaniello, +181

Resident MicrogliaInnate Immune SystemImmunologyInnate ImmunityImmune System +18

Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk

Zongqi Xia, Charles C. White, Emily K. Owen, +13

Annals of Neurology

<i>Trans</i> -pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci

Gail Chan, Charles C. White, Phoebe A. Winn, +12

Neurology Genetics

A single cell-based atlas of human microglial states reveals associations with neurological disorders and histopathological features of the aging brain

Marta Olah, Vilas Menon, Naomi Habib, +20

AgingNeurogenomicsBrain DevelopmentImmunologyMultiomics +28