Concepedia

Hiroharu Arakawa

HA

Statistics

Publications

25

Citations

1.9K

H-Index

20

Active since

1988

Affiliations

Food Research Institute(Current)

Merck Biopharma Co., Ltd. (Japan)

Central Research Laboratories (United Kingdom)

Merck & Co., Inc., Rahway, NJ, USA (United States)

Hiroharu Arakawa is an author at Food Research Institute specializing in pharmacology, medicine, and topoisomerase inhibitors.

Publications per year

1988–2009

25

Publications

25

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

Hiroshi Hirai, Yoshikazu Iwasawa, Megumu Okada et al. · Molecular Cancer Therapeutics · 2009 · 550 citations

, , +17

Effect of genistein on topoisomerase activity and on the growth of [VAL 12]Ha-ras-transformed NIH 3T3 cells

Akira Okura, Hiroharu Arakawa, Hirofumi Oka et al. · Biochemical and Biophysical Research Communications · 1988 · 439 citations

, , +7

Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure.

Hideya Komatani, Hitoshi Kotani, Yoshikazu Hara et al. · PubMed · 2001 · 100 citations

, , +17

Novel antitumor indolocarbazole compound 6-N-formylamino-12,13-dihydro-1,11- dihydroxy-13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4- c]carbazole-5,7(6H)-dione (NB-506): induction of topoisomerase I-mediated DNA cleavage and mechanisms of cell line-selective cytotoxicity.

Tomoko Yoshinari, Mami Matsumoto, Hiroharu Arakawa et al. · PubMed · 1995 · 66 citations

, , +15

Induction of topoisomerase I-mediated DNA cleavage by a new indolocarbazole, ED-110.

Tomoko Yoshinari, Akira Yamada, Daisuke Uemura et al. · PubMed · 1993 · 62 citations

, , +16

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