Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression

Kazuhiro Hasegawa, Shu Wakino, Kyoko Yoshioka, +7

Biochemical and Biophysical Research Communications

UrologyMedicineApoptosisCatalase ExpressionCell Death +6

Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function

Kazuhiro Hasegawa, Shu Wakino, Kyoko Yoshioka, +10

Journal of Biological Chemistry

ApoptosisImmunologyRenal InflammationCell DeathNephrology +16

Hepatic De Novo Lipogenesis Is Present in Liver-Specific ACC1-Deficient Mice

Naomoto Harada, Zenjun Oda, Yoshikazu Hara, +9

Molecular and Cellular Biology

Mitochondrial Acc2CholangiopathiesLoxp SequencesHepatotoxicityMetabolic Signaling +17

Rho and Rho-Kinase Activity in Adipocytes Contributes to a Vicious Cycle in Obesity That May Involve Mechanical Stretch

Yoshikazu Hara, Shu Wakino, Yoshiyuki Tanabe, +13

Science Signaling

Metabolic DisorderStress Fiber FormationMetabolic RemodelingCellular PhysiologyInsulin Signaling +22

Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure.

Hideya Komatani, Hitoshi Kotani, Yoshikazu Hara, +4

PubMed

Drug Resistance AnalysisChemoprevention StrategyBiochemistryBcrp Expression VectorMedicine +12

A Randomized, Placebo-Controlled Trial of Acupuncture in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Masao Suzuki, Shigeo Muro, Takashi Omori, +15

Archives of Internal Medicine

Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I.

Tomoko Yoshinari, Mitsuru Ohkubo, Kazuhiro Fukasawa, +7

PubMed

Molecular BiologyPharmacotherapyAntimicrobial ChemotherapyChemical BiologyCulture Medium +14

Cystatin-like metastasis-associated protein mRNA expression in human colorectal cancer is associated with both liver metastasis and patient survival.

Tohru Utsunomiya, Yoshikazu Hara, Akemi Kataoka, +4

PubMed

T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy

Naoki Sugano, Shu Wakino, Takeshi Kanda, +13

Kidney International

UrologyRenal FunctionMedicineRenal InflammationSubtotal Nephrectomy +7

Role of mineralocorticoid receptor/Rho/Rho-kinase pathway in obesity-related renal injury

Hirobumi Tokuyama, Shu Wakino, Yoshikazu Hara, +9

International Journal of Obesity