Alan R. Rendina

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Philip A. Harris, Scott B. Berger, Jae Uk Jeong et al. · Journal of Medicinal Chemistry · 2017 · 475 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1<i>H</i>-pyrazolo[3,4-<i>c</i>]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Donald Pinto, Michael J. Orwat, Stephanie C. Koch et al. · Journal of Medicinal Chemistry · 2007 · 397 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

DNA-Encoded Library Screening Identifies Benzo[<i>b</i>][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

Philip A. Harris, Bryan W. King, Deepak Bandyopadhyay et al. · Journal of Medicinal Chemistry · 2016 · 275 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

New IDH1 mutant inhibitors for treatment of acute myeloid leukemia

Ujunwa Cynthia Okoye-Okafor, Boris Bartholdy, Jessy Cartier et al. · Nature Chemical Biology · 2015 · 176 citations · Full text

Medicine, Hematology, Oncology +12

Cyclohexanedione Herbicides Are Selective and Potent Inhibitors of Acetyl-CoA Carboxylase from Grasses

Alan R. Rendina, Judy M. Felts · PLANT PHYSIOLOGY · 1988 · 125 citations · Full text

Agriculture, Plant Biology, Plant Sciences +16