Deborah Dhuyvetter

BACE1 Inhibition Induces a Specific Cerebrospinal Fluid β-Amyloid Pattern That Identifies Drug Effects in the Central Nervous System

Niklas Mattsson, Lawrence Rajendran, Henrik Zetterberg et al. · PLoS ONE · 2012 · 70 citations · Full text

Neurochemical Biomarkers, Amyloid Precursor Protein, Synaptic Signaling +20

Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus

David C. McGowan, Florence Herschke, Frederik Pauwels et al. · Journal of Medicinal Chemistry · 2016 · 40 citations

Internal Screening Effort, Viral Hepatitis, Medicine +15

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain

Kouki Fuchino, Yasunori Mitsuoka, Moriyasu Masui et al. · Journal of Medicinal Chemistry · 2018 · 33 citations · Full text

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization

Kenji Nakahara, Kouki Fuchino, Kazuo Komano et al. · Journal of Medicinal Chemistry · 2018 · 32 citations · Full text

Chemical Biology, Pharmaceutical Chemistry, Pre-clinical Pharmacology +20

Young to Middle-Aged Dogs with High Amyloid-β Levels in Cerebrospinal Fluid are Impaired on Learning in Standard Cognition tests

Herman Borghys, Bianca Van Broeck, Deborah Dhuyvetter et al. · Journal of Alzheimer s Disease · 2016 · 29 citations · Full text