DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

Olga A. Guryanova, Kaitlyn Shank, Barbara Spitzer, +36

Nature Medicine

Hematological MalignancyChromatinMixed-phenotype Acute LeukemiaAcute Myeloid LeukemiaDnmt3a Mutations +8

Mutational Cooperativity Linked to Combinatorial Epigenetic Gain of Function in Acute Myeloid Leukemia

Alan H. Shih, Yanwen Jiang, Cem Meydan, +25

Cancer Cell

ChromatinCombinatorial Epigenetic GainChromatin RemodelingEpigenetic ChangeGenetics +9

Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis

Aaron D. Viny, Christopher J. Ott, Barbara Spitzer, +14

The Journal of Experimental Medicine

Dose-dependent RoleMixed-phenotype Acute LeukemiaImmunologyPathologySmc3 Deletion +19

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms

Sara C. Meyer, Matthew D. Keller, Sophia Chiu, +35

Cancer Cell

Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in <i>IDH2</i> - and <i>TET2</i> -Mutant Acute Myeloid Leukemia

Alan H. Shih, Cem Meydan, Kaitlyn Shank, +15

Cancer Discovery

Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms

Neha Bhagwat, Priya Koppikar, Matthew D. Keller, +11

Blood

Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

Hiroyoshi Kunimoto, Cem Meydan, Abbas Nazir, +11

Cancer Cell

ChromatinGenome InstabilityChromatin RemodelingEpigenetic ChangeGenetics +9

LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone

Jonas S. Jutzi, Maria Kleppe, Jennifer Dias, +8

HemaSphere

JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition

Anna Sophia McKenney, Allison N. Lau, Amritha Varshini Hanasoge Somasundara, +20

Journal of Clinical Investigation

Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells

Olga A. Guryanova, Yen K. Lieu, Francine E. Garrett-Bakelman, +19

Leukemia

Progenitor CellsHematological MalignancyLineage PlasticityDevelopmental BiologyMedicine +10