Cancer therapy shapes the fitness landscape of clonal hematopoiesis

Kelly L. Bolton, Ryan Ptashkin, Teng Gao, +61

Nature Genetics

Hematological MalignancyTumor HeterogeneityMalignant Blood DisorderHematologyFitness Landscape +3

Loss of BAP1 function leads to EZH2-dependent transformation

Lindsay M. LaFave, Wendy Béguelin, Richard P. Koche, +28

Nature Medicine

ChromatinSignal TransductionSignal RecognitionMolecular BiologyMedicine +1

Toxicity and response after CD19-specific CAR T-cell therapy in pediatric/young adult relapsed/refractory B-ALL

Kevin J. Curran, Steven Margossian, Nancy A. Kernan, +23

Blood

Cell TherapyMixed-phenotype Acute LeukemiaImmunologyImmunotherapeuticsT Cells +16

Genetic alterations of the cohesin complex genes in myeloid malignancies

Swapna Thota, Aaron D. Viny, Hideki Makishima, +6

Blood

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

Olga A. Guryanova, Kaitlyn Shank, Barbara Spitzer, +36

Nature Medicine

Hematological MalignancyChromatinMixed-phenotype Acute LeukemiaAcute Myeloid LeukemiaDnmt3a Mutations +8

Off-the-shelf EBV-specific T cell immunotherapy for rituximab-refractory EBV-associated lymphoma following transplantation

Susan E. Prockop, Ekaterina Doubrovina, Stephanie Suser, +30

Journal of Clinical Investigation

Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis

Aaron D. Viny, Christopher J. Ott, Barbara Spitzer, +14

The Journal of Experimental Medicine

Dose-dependent RoleMixed-phenotype Acute LeukemiaImmunologyPathologySmc3 Deletion +19

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms

Sara C. Meyer, Matthew D. Keller, Sophia Chiu, +35

Cancer Cell

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Su‐Fern Tan, Xin Liu, Todd E. Fox, +22

Oncotarget

Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis

Teng Gao, Ryan Ptashkin, Kelly L. Bolton, +28

Nature Communications