Single-cell mutation analysis of clonal evolution in myeloid malignancies

Linde A. Miles, Robert L. Bowman, Tiffany R. Merlinsky, +21

Nature

Hematological MalignancyTumor HeterogeneityHematologyMyeloid NeoplasiaSingle-cell Genomics +5

Genetic alterations of the cohesin complex genes in myeloid malignancies

Swapna Thota, Aaron D. Viny, Hideki Makishima, +6

Blood

DNA methylation disruption reshapes the hematopoietic differentiation landscape

Franco Izzo, Stanley Chun-Wei Lee, Asaf Poran, +19

Nature Genetics

ChromatinNatural SciencesGeneticsDna MethylationEpigenetic Change +6

Subtype-specific 3D genome alteration in acute myeloid leukaemia

Jie Xu, Fan Song, Huijue Lyu, +26

Nature

Hematological MalignancyChromatinMixed-phenotype Acute LeukemiaGeneticsHematology +3

Clinical and molecular predictors of response and survival following venetoclax therapy in relapsed/refractory AML

Maximilian Stahl, Kamal Menghrajani, Andriy Derkach, +16

Blood Advances

Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation

Aaron D. Viny, Robert L. Bowman, Yu Liu, +18

Cell stem cell

ChromatinTopological ControlChromatin RemodelingCohesin Members Stag1Genetics +7

Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis

Aaron D. Viny, Christopher J. Ott, Barbara Spitzer, +14

The Journal of Experimental Medicine

Dose-dependent RoleMixed-phenotype Acute LeukemiaImmunologyPathologySmc3 Deletion +19

Racial disparities in the survival of American children, adolescents, and young adults with acute lymphoblastic leukemia, acute myelogenous leukemia, and Hodgkin lymphoma

Justine M. Kahn, Theresa H.M. Keegan, Tao Li, +3

Cancer

A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes

Peter van Galen, Aaron D. Viny, Oren Ram, +11

Molecular Cell

ChromatinFunctional GenomicsEngineeringChromatin RemodelingGenetics +9

Clinical and biological implications of ancestral and non-ancestral IDH1 and IDH2 mutations in myeloid neoplasms

Remco J. Molenaar, Swapna Thota, Yasunobu Nagata, +21

Leukemia

Hematological MalignancyBiological ImplicationsSomatic VariantGeneticsHematology +6