CTLA-4 is a second receptor for the B cell activation antigen B7.

Peter S. Linsley, William Brady, M Urnes, +3

The Journal of Experimental Medicine

Functional PropertiesFunctional InteractionsAdaptive Immune SystemImmunologyImmune Regulation +12

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

Vijay K. Kuchroo, Mercy Prabhu Das, Julia A. Brown, +6

Cell

Th1/th2 Developmental PathwaysDisease TherapyAutoimmune DiseaseLymphocyte DevelopmentImmune Cell Development +9

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

Deborah J. Lenschow, Yijun Zeng, J. Richard Thistlethwaite, +5

Science

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

P S Linsley, JoAnne L. Greene, William Brady, +3

Immunity

Human B7-1Signal TransductionAutoimmune DiseaseCtla-4 ReceptorsImmunology +11

CTLA-4 ligation blocks CD28-dependent T cell activation.

Theresa L. Walunas, Christina Y. Bakker, Jeffrey A. Bluestone

The Journal of Experimental Medicine

Ctla-4 LigationT-regulatory CellImmunologyImmune RegulationCell Death +15

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

Gordon J. Freeman, Vassiliki A. Boussiotis, Anukanth Anumanthan, +6

Immunity

Initial ProductionImmunologyAutoimmunitySystems BiologyMedicine +1

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

Claude Gimmi, G J Freeman, John G. Gribben, +2

Proceedings of the National Academy of Sciences

Adaptive Immune SystemHla ImmunogeneticsImmunologyImmunodominanceImmunologic Mechanism +16

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

M H Sayegh, Enver Akalin, W W Hancock, +4

The Journal of Experimental Medicine

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

Wayne W. Hancock, Mohamed H. Sayegh, Xiang-Guang Zheng, +3

Proceedings of the National Academy of Sciences

Cell TherapyHeart FailureImmunologyTransplantation MedicineCd40 Ligand +16

BOTH ALLOANTIGEN-DEPENDENT AND -INDEPENDENT FACTORS INFLUENCE CHRONIC ALLOGRAFT REJECTION

Stefan G. Tullius, Nicholas L. Tilney

Transplantation

Solid Organ TransplantationImmunologyTransplantation MedicinePathologyImmunotherapy +14