Cereblon is recruited to aggresome and shows cytoprotective effect against ubiquitin-proteasome system dysfunction

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Tohru Kitada, Shuichi Asakawa, Nobutaka Hattori et al. · Nature · 1998 · 5.2K citations

Life Sciences, Genetics, Molecular Genetics +10

Identification of a Primary Target of Thalidomide Teratogenicity

Takumi Ito, Hideki Ando, Takayuki Suzuki et al. · Science · 2010 · 2.1K citations

Life Sciences, Developmental Biology, Molecular Biology +13

The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress

Yoshiharu Kawaguchi, Jeffrey J. Kovacs, Adam C. McLaurin et al. · Cell · 2003 · 1.5K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

Brinda Ravikumar · Human Molecular Genetics · 2002 · 1.1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

Antonia Lopez‐Girona, Derek Mendy, Takumi Ito et al. · Leukemia · 2012 · 798 citations · Full text

Medicine, Oncology, Pharmacology +15