Interspecies differences in the metabolism of methotrexate: An insight into the active site differences between human and rabbit aldehyde oxidase

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

David C. Pryde, Deepak Dalvie, Qiyue Hu et al. · Journal of Medicinal Chemistry · 2010 · 346 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +10

The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition

Ken Okamoto, Koji Matsumoto, Russ Hille et al. · Proceedings of the National Academy of Sciences · 2004 · 285 citations · Full text

Life Sciences, Biochemistry, Chemistry +14

7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate.

Samuel A. Jacobs, Ronald G. Stoller, Bruce A. Chabner et al. · Journal of Clinical Investigation · 1976 · 256 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15

Involvement of the <i>narJ</i> and <i>mob</i> gene products in distinct steps in the biosynthesis of the molybdoenzyme nitrate reductase in <i>Escherichia coli</i>

Tracy Palmer, Claire‐Lise Santini, Chantal Iobbi‐Nivol et al. · Molecular Microbiology · 1996 · 162 citations

Life Sciences, Microbiology, Molecular Biology +11

In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver.

Mohammad‐Reza Rashidi, John A. Smith, Stephen E. Clarke et al. · PubMed · 1997 · 157 citations

Life Sciences, Biochemistry, Pharmacology +11