Samuel A. Jacobs

Use of Plasma Pharmacokinetics to Predict and Prevent Methotrexate Toxicity

Ronald G. Stoller, Kenneth R. Hande, Samuel A. Jacobs et al. · New England Journal of Medicine · 1977 · 395 citations

Drug Safety, Standard Deviations, Pharmacokinetic Modeling +12

HER2 Activating Mutations Are Targets for Colorectal Cancer Treatment

Shyam M. Kavuri, Naveen Jain, Francesco Galimi et al. · Cancer Discovery · 2015 · 286 citations · Full text

The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.

Matthew Peters, Samuel A. Jacobs, Marc Ehlers et al. · The Journal of Experimental Medicine · 1996 · 283 citations · Full text

Immune Regulation, Immunology, Immunologic Mechanism +19

Anthracyclines in Early Breast Cancer: The ABC Trials—USOR 06-090, NSABP B-46-I/USOR 07132, and NSABP B-49 (NRG Oncology)

Joanne L. Blum, Patrick J. Flynn, Greg Yothers et al. · Journal of Clinical Oncology · 2017 · 280 citations

7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate.

Samuel A. Jacobs, Ronald G. Stoller, Bruce A. Chabner et al. · Journal of Clinical Investigation · 1976 · 256 citations · Full text

Medicinal Chemistry, Pharmacological Study, High Dose Methotrexate +14