Stephen E. Clarke

5-Chloro-<i>N</i>-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046):  A Potent, Selective, and Orally Bioavailable 5-HT₆ Receptor Antagonist

Steven M. Bromidge, Anthony M. Brown, Stephen E. Clarke et al. · Journal of Medicinal Chemistry · 1999 · 170 citations · Full text

Drug Target, Altmetric Attention Score, 4-Methoxy-3-piperazin-1-yl- Phenyl +18

Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism.

Kathryn E. Kenworthy, Stephen E. Clarke, J. Andrews et al. · PubMed · 2001 · 160 citations

Unusual Kinetics, Experimental Pharmacology, Physiologically-based Pharmacokinetic Modeling +16

In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver.

Mohammad‐Reza Rashidi, John A. Smith, Stephen E. Clarke et al. · PubMed · 1997 · 157 citations

Bioorganic Chemistry, Milk Xanthine Oxidase, Redox Biology +18

In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(-)-carvedilol.

Harriet G. Oldham, Stephen E. Clarke · PubMed · 1997 · 150 citations

Multivariate Correlation Analysis, Metabolomic Profiling, Secondary Metabolite +19

MULTISITE KINETIC ANALYSIS OF INTERACTIONS BETWEEN PROTOTYPICAL CYP3A4 SUBGROUP SUBSTRATES: MIDAZOLAM, TESTOSTERONE, AND NIFEDIPINE

Aleksandra Galetin, Stephen E. Clarke, J. Brian Houston · Drug Metabolism and Disposition · 2003 · 138 citations