5-Chloro-<i>N</i>-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): A Potent, Selective, and Orally Bioavailable 5-HT₆ Receptor Antagonist

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXT5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): A Potent, Selective, and Orally Bioavailable 5-HT6 Receptor AntagonistSteven M. Bromidge, Anthony M. Brown, Stephen E. Clarke, Kathy Dodgson, Tracey Gager, Helen L. Grassam, Phil M. Jeffrey, Graham F. Joiner, Frank D. King, Derek N. Middlemiss, Stephen F. Moss, Helen Newman, Graham Riley, Carol Routledge, and Paul WymanView Author Information Departments of Medicinal Chemistry, Neuroscience Research, and Drug Metabolism and Pharmacokinetics, SmithKline Beecham Pharmaceuticals, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, England Cite this: J. Med. Chem. 1999, 42, 2, 202–205Publication Date (Web):January 5, 1999Publication History Received21 September 1998Published online5 January 1999Published inissue 1 January 1999https://doi.org/10.1021/jm980532eCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1124Altmetric-Citations153LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (82 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Antagonists,Central nervous system,Peptides and proteins,Receptors,Rodent models Get e-Alerts