Kathryn E. Kenworthy

In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model

J. Brian Houston, Kathryn E. Kenworthy · Drug Metabolism and Disposition · 2000 · 392 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

Evita van de Steeg, Viktor Stránecký, Hana Hartmannová et al. · Journal of Clinical Investigation · 2012 · 385 citations · Full text

Life Sciences, Biochemistry, Genetics +17

Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs

Evita van de Steeg, Els Wagenaar, Cornelia M.M. van der Kruijssen et al. · Journal of Clinical Investigation · 2010 · 227 citations · Full text

Medicine, Biochemistry, Pharmacology +16

Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism.

Kathryn E. Kenworthy, Stephen E. Clarke, J. Andrews et al. · PubMed · 2001 · 160 citations

Medicine, Biochemistry, Pharmacology +17

Cyclosporine Inhibition of Hepatic and Intestinal CYP3A4, Uptake and Efflux Transporters: Application of PBPK Modeling in the Assessment of Drug-Drug Interaction Potential

Michael Gertz, Catherine M. Cartwright, Michael Hobbs et al. · Pharmaceutical Research · 2012 · 148 citations

Pharmacy, Pharmacokinetics, Pharmacology +17