Assessment of plasma antioxidant levels in type 2 diabetes patients

Abstract

Free radicals and related species have attracted a great deal of attention in recent years. Type 2 diabetes is the commonest form of diabetes and associated with multiple metabolic derangements that result in the excessive production of reactive oxygen species and oxidative stress. To counteract the harmful effects of free radicals, antioxidant defense mechanism operates to detoxify or scavenge these free radicals. In addition to antioxidant enzyme activities, the capacity of the antioxidant system to cope with or trap the free radicals generated under normal or pathological conditions was evaluated by measuring the level of total antioxidant status. It reflects the status of α-tocopherol, vitamin A, β-carotene, ascorbic acid, albumin, uric acid and other antioxidants. These extracellular nonenzymatic antioxidants delay or inhibit the oxidative process. Enhanced lipid peroxidation increases the need for lipid soluble antioxidants, such as α-tocopherol and vitamin A and β-carotene. In this present study we have evaluated the importance of these markers in Indian subjects. we have investigated antioxidant status in the form of estimation of plasma/serum Zinc, Ascorbic acid, Albumin, Uric acid & Total bilirubin levels with antioxidant enzymes would greatly help in preventing or postponing the onset of diabetes.