Concepedia

Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation

Norimichi Koitabashi, Takeshi Aiba, Geoffrey G. Hesketh, J. G. Rowell, Manling Zhang, Eiki Takimoto, Gordon F. Tomaselli, David A. Kass

Journal of Molecular and Cellular Cardiology · 2009 · 172 citations · 38 references

Concepts

Cardiac MuscleCardiomyopathyMolecular PhysiologySignal TransductionSignaling PathwayG Protein-coupled ReceptorCell SignalingCyclic Gmp/pkg-dependent InhibitionPhysiologyTrpc6 Channel ActivityCardiomyocyte Nfat ActivationCellular BiochemistryMedicineCell BiologyCellular PhysiologyCell Physiology

References

38

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

Jeffery D. Molkentin, Jianrong Lu, Christopher L. Antos et al. · Cell · 1998 · 2.6K citations · Full text

Cardiac Muscle, Transcriptional Regulation, Cardiomyopathy +8

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

Thomas Hofmann, Alexander G. Obukhov, Michael Schaefer et al. · Nature · 1999 · 1.5K citations

Molecular Pharmacology, Proteinlipid Interaction, Signal Transduction +12

A Mutation in the <i>TRPC6</i> Cation Channel Causes Familial Focal Segmental Glomerulosclerosis

Michelle P. Winn, Peter J. Conlon, Kelvin L. Lynn et al. · Science · 2005 · 1.1K citations

Glomerular Disease, Renal Pathology, Immunology +17

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

Eiki Takimoto, Hunter C. Champion, Manxiang Li et al. · Nature Medicine · 2005 · 894 citations

Cardiac Muscle, Cardiomyopathy, Molecular Physiology +9

The Transient Receptor Potential Protein Homologue TRP6 Is the Essential Component of Vascular α<sub>1</sub>-Adrenoceptor–Activated Ca<sup>2+</sup>-Permeable Cation Channel

Ryuji Inoue, Takaharu Okada, Hitoshi Onoue et al. · Circulation Research · 2001 · 592 citations · Full text