Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

Dong I. Lee, Guangshuo Zhu, Takashi Sasaki, +17

Nature

Molecular PhysiologyDisease MechanismMedicinePhysiologyVascular Biology +3

Avoidance of Transient Cardiomyopathy in Cardiomyocyte-Targeted Tamoxifen-Induced MerCreMer Gene Deletion Models

Norimichi Koitabashi, Djahida Bedja, Ari Zaiman, +5

Circulation Research

Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice

Eiki Takimoto, Norimichi Koitabashi, Steven Hsu, +9

Journal of Clinical Investigation

Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation

Norimichi Koitabashi, Takeshi Aiba, Geoffrey G. Hesketh, +5

Journal of Molecular and Cellular Cardiology

Cardiac MuscleCardiomyopathyMolecular PhysiologySignal TransductionSignaling Pathway +11

Serine Protease Inhibitor 6 Protects Cytotoxic T Cells from Self-Inflicted Injury by Ensuring the Integrity of Cytotoxic Granules

Manling Zhang, Sun-Mi Park, Yue Wang, +6

Immunity

InflammationT-regulatory CellImmunologySelf-inflicted InjuryCell Death +8

Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH

Runjie Zhang, Ying Wang, Lei Chen, +19

Acta Biomaterialia

Regenerative MedicineCardiac MuscleGenetically-deleting ThreeMedicineImmunology +7

Myocardial Remodeling Is Controlled by Myocyte-Targeted Gene Regulation of Phosphodiesterase Type 5

Manling Zhang, Eiki Takimoto, Steven Hsu, +9

Journal of the American College of Cardiology

Cardiac MusclePhosphodiesterase Type 5Systems BiologyMolecular PhysiologySignal Transduction +10

PDE5 inhibitor efficacy is estrogen dependent in female heart disease

H. Sasaki, Takahiro Nagayama, Robert M. Blanton, +13

Journal of Clinical Investigation

Heart FailureCgmp SynthesisCardiovascular PharmacologyGynecologyPharmacotherapy +23

Derivation of Porcine Embryonic Stem-Like Cells from In Vitro-Produced Blastocyst-Stage Embryos

Daorong Hou, Yong Jin, Xiaowei Nie, +11

Scientific Reports

Apolipoprotein E deficiency accelerates atherosclerosis development in miniature pigs

Bin Fang, Xueyang Ren, Ying Wang, +17

Disease Models & Mechanisms