Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

Dong I. Lee, Guangshuo Zhu, Takashi Sasaki, +17

Nature

Molecular PhysiologyDisease MechanismMedicinePhysiologyVascular Biology +3

PGC-1α Regulates Expression of Myocardial Mitochondrial Antioxidants and Myocardial Oxidative Stress After Chronic Systolic Overload

Zhongbing Lu, Xin Xu, Xinli Hu, +8

Antioxidants and Redox Signaling

Heart FailurePgc-1α Regulates ExpressionSevere Lv HypertrophyReactive Oxygen SpeciesRedox Biology +16

AMP Activated Protein Kinase-α2 Deficiency Exacerbates Pressure-Overload–Induced Left Ventricular Hypertrophy and Dysfunction in Mice

Ping Zhang, Xinli Hu, Xin Xu, +8

Hypertension

Cardiac MuscleCardiomyopathyHeart FailureMolecular PhysiologyDevelopmental Biology +12

Oxidative Stress Regulates Left Ventricular PDE5 Expression in the Failing Heart

Zhongbing Lu, Xin Xu, Xinli Hu, +11

Circulation

Monoamine Oxidase B Prompts Mitochondrial and Cardiac Dysfunction in Pressure Overloaded Hearts

Nina Kaludercic, Andrea Carpi, Takahiro Nagayama, +13

Antioxidants and Redox Signaling

Inducible Nitric Oxide Synthase Deficiency Protects the Heart From Systolic Overload–Induced Ventricular Hypertrophy and Congestive Heart Failure

Ping Zhang, Xin Xu, Xinli Hu, +3

Circulation Research

Heart FailureCardiovascular FunctionOxidative StressInos MonomerCongestive Heart Failure +14

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

Brian L. Lin, Damian Matera, Julia F. Doerner, +27

Proceedings of the National Academy of Sciences

Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation

Ning Feng, Sabine Huke, Guangshuo Zhu, +11

Proceedings of the National Academy of Sciences

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

Mark J. Ranek, Kristen M. Kokkonen-Simon, Anna Chen, +13

Nature

Cardiac MuscleCardiomyopathyMolecular PhysiologySignal TransductionMedicine +6

Extracellular Superoxide Dismutase Deficiency Exacerbates Pressure Overload–Induced Left Ventricular Hypertrophy and Dysfunction

Zhongbing Lu, Xin Xu, Xinli Hu, +8

Hypertension

Extracellular Superoxide DismutaseHeart FailureGlutathione DisulfideLipid PeroxidationCardiovascular Function +14