Concepedia

Nfat Activation

NFAT Activation is a signaling mechanism within the B cell receptor signaling pathway that refers to the calcium-dependent dephosphorylation and subsequent nuclear translocation of Nuclear Factor of Activated T cells (NFAT) transcription factors, enabling their regulation of gene expression essential for B cell activation and immune response.

1.1K

Publications

80.6K

Citations

6.1K

Authors

1.3K

Institutions

Publications per year

2017–2026

185

Parents

Publications

1.1K

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

Yongqing Wu, Madhuri Borde, Vigo Heissmeyer et al. · Cell · 2006 · 1.2K citations · Full text

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The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

Gustavo Martínez, Renata M. Pereira, Tarmo Äijö et al. · Immunity · 2015 · 856 citations · Full text

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Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

Yukiko Tone, Keiji Furuuchi, Yoshitsugu Kojima et al. · Nature Immunology · 2007 · 786 citations

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CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

Jiehui Deng, Eric S. Wang, Russell W. Jenkins et al. · Cancer Discovery · 2017 · 781 citations · Full text

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The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

Jugnu Jain, Zoe Miner, Tom K. Kerppola et al. · Nature · 1993 · 769 citations

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1–5 of 1.1K

Authors

6.1K

  1. AR
    Anjana Rao

    Harvard University, United States

    38 publications · 8.2K citations

    35

    h-index

  2. JD
    Jeffery D. Molkentin

    Cincinnati Children's Hospital Medical Center, United States

    22 publications · 3.1K citations

    22

    h-index

  3. PG
    Patrick G. Hogan

    Harvard University, United States

    17 publications · 4.8K citations

    17

    h-index

  4. ES
    Edgar Serfling

    University of Würzburg, Germany

    16 publications · 1.3K citations

    16

    h-index

  5. MF
    Manuel Fresno

    Centro de Biología Molecular Severo Ochoa, Spain

    13 publications · 1.3K citations

    13

    h-index

1–5 of 6.1K

Institutions

1.3K

  1. Harvard University

    Cambridge, United States

    63 h-index

    344 publications

    63.6K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    39 h-index

    129 publications

    20.4K citations

  3. Cincinnati Children's Hospital Medical Center

    Cincinnati, United States

    24 h-index

    85 publications

    16.3K citations

  4. Stanford University

    Stanford, United States

    23 h-index

    81 publications

    13.6K citations

  5. National Institutes of Health

    Bethesda, United States

    22 h-index

    81 publications

    6.8K citations

  6. Inserm

    Paris, France

    21 h-index

    129 publications

    7.2K citations

  7. Universidad Autónoma de Madrid

    Madrid, Spain

    20 h-index

    87 publications

    9.2K citations

  8. New York University

    New York, United States

    19 h-index

    75 publications

    4K citations

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Venues

  1. Journal of Biological Chemistry

    JBC · 130 publications · 11.6K citations

    67

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  2. Proceedings of the National Academy of Sciences

    PNAS · 50 publications · 6.4K citations

    43

    h-index

  3. The Journal of Immunology

    JI · 76 publications · 4.4K citations

    40

    h-index

  4. Molecular and Cellular Biology

    MCB · 44 publications · 4.5K citations

    35

    h-index

  5. PLoS ONE

    28 publications · 1.2K citations

    21

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