Patrick G. Hogan

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

Stefan Feske, Yousang Gwack, Murali Prakriya et al. · Nature · 2006 · 2.2K citations

Crac Channel Function, Immunogenetics, Molecular Immunology +10

Orai1 is an essential pore subunit of the CRAC channel

Murali Prakriya, Stefan Feske, Yousang Gwack et al. · Nature · 2006 · 1.3K citations

Protein Secretion, Signal Transduction, Biochemistry +9

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

Gustavo Martínez, Renata M. Pereira, Tarmo Äijö et al. · Immunity · 2015 · 805 citations · Full text

Transcriptional Regulation, Signal Transduction, Cell Regulation +9

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8 ⁺ T cell exhaustion

Hyungseok Seo, Joyce Chen, Edahí González‐Avalos et al. · Proceedings of the National Academy of Sciences · 2019 · 717 citations · Full text

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

Masatsugu Oh‐hora, Megumi Yamashita, Patrick G. Hogan et al. · Nature Immunology · 2008 · 584 citations · Full text

T Cell Activation, Molecular Physiology, Signal Transduction +9