Concepedia

Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch

Hai Wang, Danqing Hu, Cheng Yang, Qiong Gao, Kun Liu, Nikita Mani, Amy Tang, Radhika Iyer, Beixue Gao, Leyu Sun,

Nature Immunology · 2025 · 42 citations · 29 references

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29

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik et al. · Nature · 2013 · 4K citations · Full text

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Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

Wei Xu, Hui Yang, Ying Liu et al. · Cancer Cell · 2011 · 2.8K citations · Full text

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TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

Liang Zhou, Jared E. Lopes, Mark M. W. Chong et al. · Nature · 2008 · 1.8K citations

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The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells

Francesca Fallarino, Ursula Grohmann, Sylvaine You et al. · The Journal of Immunology · 2006 · 1K citations · Full text

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Mitochondrial complex III is essential for suppressive function of regulatory T cells

Samuel E. Weinberg, Benjamin D. Singer, Elizabeth M. Steinert et al. · Nature · 2019 · 489 citations

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